Mill Spring, Missouri, is located along the Black River in Wayne County in the Southeast portion of the state. It started as a railroad and logging town.

One of the first residents in the area was Captain William T. Leeper, who became one of Wayne County’s most prominent men. Raised in Tennessee, he moved to the area in 1857 and purchased 225 acres of land. The following year, he was elected county surveyor, a position he held until the Civil War broke out. He then organized Company D, Twelfth Regiment, of the Missouri State Militia, of which he became captain.

After he returned from the war, he represented Wayne County in the State Legislature. During that time, he influenced the St. Louis, Iron Mountain, and Southern Railway to extend their line through Piedmont to Mill Spring and Williamsville rather than the initially planned routes through Patterson and Greenville. As an incentive, he donated a right-of-way through his land, and even though this route required a cut through two mountains, the railroad agreed.

When the St. Louis, Iron Mountain, and Southern Railway extended its line South from Pilot Knob to Piedmont in 1871, a hub of large logging operations emerged to meet the demands of a country desperately trying to rebuild and expand after the Civil War. More familiarly called the Iron Mountain Railway, this historic line would eventually run from St. Louis, Missouri, to Texarkana, Arkansas, and several locations in Southeast Missouri.

Growth centers developed quickly along the Iron Mountain Railroad, and large sawmills were quickly operated. The railroad laid out the town of Mill Spring in November 1871. Because it was situated near a natural spring that powered a sawmill, the new community was called Mill Spring. Just 1.5 miles to the northwest, Leeper Station was established on the North end of Captain William T. Leeper’s farm. The town of Leeper would be established here ten years later.

By 1872, the Clarkson Sawmill Company, which had been operating in Iron County since 1870 near the Iron Mountain tracks, moved its operations to Mill Spring and soon became the county’s largest milling operation. Clarkson’s sawmills furnished all the bridge timber and the cross ties to the Iron Mountain Railway.

A post office was established in Mill Spring in 1874, and before long, the town boasted three stores, two hotels, and a population of about 250 people.

James Livingston Clarkson, originally from Essex County, Virginia, owned the large Clarkson Sawmill. At 16, he joined the Confederate army as a member of the Ninth Virginia Cavalry under the command of General J.E.B. Stuart. After the war, he spent some time in Iowa before moving to southeastern Missouri, where he established a lumber business. Clarkson was very successful, and with the organization of the Williamsville, Greenville, and St. Louis Railroad, he expanded his lumber business throughout Wayne County. He soon built a massive mill in Greenville, which became the largest in the state, with about 700 employees. By 1880, the company milled four million board feet of lumber.

The nearby Leeper Station developed into the town of Leeper in 1881 when the Mill Spring, Current River, & Barnesville Railroad was built from that point to the Clarkson Sawmill Company in Greenwood. Clarkson’s interests built this railroad, which later became the Missouri Southern Railway, to connect the sawmill to the Iron Mountain Railroad. In 1881, it was 16 miles long, but as the virgin timberline receded, it reached Bunker, 54 miles away. Still, it remained merely a rail junction point until the Greenwood Valley Mill burned in 1888. Afterward, they built a new mill in Leeper, and the town began to boom. One of the state’s largest sawmills, it was among the first to use band saws. The population of Leeper soon doubled and boasted a post office, two hotels, two saloons, a school, and four mercantile establishments.

Meanwhile, early in the 1890s, Dr. Richard Owens, who hailed from Tennessee, built an office and drug store on the corner of Second and Birch Streets in Mill Spring. He also ran an undertaking service from a room in the back. His family attended the Mill Spring Christian Church, established five years earlier on Second Street, on land donated by the Leeper family.

One of the most serious collisions in the history of the Iron Mountain Railroad occurred two miles South of Mill Spring in January 1902 when two freight trains met head-on. Unfortunately, a flagman was sent from Williamsville to Mill Spring to flag the southbound freight but misunderstood his orders and went to Piedmont instead. When the accident was imminent, the crew of the northbound freight train saw the other one while rounding a curve, at which point its fireman and a brakeman left the train. However, on the other train, the fireman and brakeman were killed outright, and an engineer was fatally injured. In addition, a car of cattle and goats, another of mules, one of lumber, and two flat cars and one boxcar were utterly demolished.

Unfortunately for Mill Spring and nearby Leeper, lumber prices dropped so much that large-scale operations became unprofitable. Operations at the Clarkson Mill gradually slackened, and in 1905, the operation was suspended. Afterward, both towns began to dwindle, and both turned to farming. Mill Spring still had a population of 360 in 1912. The Ozark Hotel in Leeper remained a primary destination in the early 20th century, considered one of the most elaborate resorts in Southeast Missouri.

One of the most famous people to visit the area was George Sisler, a baseball player for the St. Louis Browns. Sisler held the Major League Baseball record for most single hits in a season from 1920–2004. One year, Sisler came to Leeper to visit his friend Herman Radke and do some quail hunting. Radke often loaded the hunters into his Ford truck and drove down the railroad tracks. One evening, while waiting for the train to pass, Radke, Dr. Owens, Sisler, and Paul Simmons all waited in the station. Dr. Owens found a deck of playing cards, and the men began to gamble in a game of poker. Three men barged into the station wearing masks shortly into their game. Two of the men were armed and demanded the poker players hand over their money, jewelry, and anything of value. After the masked men left, Dr. Owens recognized one of the men, alerted authorities, and apprehended the three men. However, during the court trial, in which Sisler had to travel back twice, the Judge determined that due to the men’s gambling, no matter how small, the robbers were innocent and set free.

Though Leeper boomed into a larger town in the late 19th century, its famous Ozark Hotel was for sale in the 1940s, and it lost its post office along the way. Today, only a scattering of homes remains.

Meanwhile, Mill Spring survived, and the area remains home to about 160 people. Though it is far from an “official ghost town,” it is not the city it once was. Unfortunately, its post office closed in 2014.

 

©Kathy Alexander/Legends of America, updated October 2026.

Also See:

Ghost Towns Across America

Missouri Main Page

Missouri Ghost Towns

Lost Landmarks & Vanished Sites

Sources:

Ellinghouse, Cletis R., Swindled: Wayne County’s Turbulence, 1868-1904, XLIBRIS, 2012
Genealogy Trails
National Park Service
Wayne County Journal-Banner
Wikipedia