The Missouri Fur Company, also known as the St. Louis Missouri Fur Company and the Manuel Lisa Trading Company, was one of the earliest fur trading companies in St. Louis, Missouri. It was dissolved and reorganized several times during its more than 20 years of operation, using various names until it was finally dissolved in 1830.

In the Spring of 1807, Manuel Lisa organized an expedition up the Missouri River with 50-60 men who built Fort Raymond at the confluence of the Yellowstone and Big Horn Rivers in present-day Montana. After thoroughly working the area and obtaining thousands of pelts, they returned to St. Louis. He then formed the St. Louis, Missouri Fur Company in the winter of 1808-09 with several partners, including Pierre Chouteau, Sr., Auguste Chouteau, Jr., Andrew Henry, Pierre Menard, Benjamin Wilkinson, Reuben Lewis,  William Clark, Sylvestre Labbadie, and William Morrison.

The first expedition of the newly formed company was for the Louisiana Territory Governor, Meriwether Lewis, to return a Mandan Indian to his people in the spring of 1809.

After completing this mission, they prepared for a second expedition that included 13 river craft to travel up the Missouri River, first heading toward Fort Mandan in North Dakota. The company then established several forts along the Missouri and Nebraska Rivers and traded with the Sioux, Arikara, Mandan, and Blackfeet Indians.

The company periodically returned the thousands of pelts it collected to St. Louis, Missouri, where William Clark served as the company’s agent. The War of 1812 created difficulties for the St. Louis Fur Company, and they were forced out of the dangerous Dakota country. The partnership was dissolved the same year. However, in 1819, it reorganized as the Missouri Fur Company with partners Manuel Lisa, Thomas Hempstead, Andrew Woods, Joseph Perkins, Joshua Pilcher, Moses B. Carson, and John Zenoni.

Manuel Lisa and his wife returned to Fort Lisa near Omaha, Nebraska, while Joshua Pilcher moved from camp to camp, trading with the Indians. When Pilcher returned to Fort Lisa, Manuel Lisa was in poor health. Lisa died on August 12, 1820. Afterward, Thomas Hempstead served as the business manager, based in St. Louis, Missouri. However, the fur trade was becoming unstable, and after an Arikara war party robbed two of their posts, their debts began to mount. However, the company persevered and soon pushed farther west, building Fort Benton in Montana and trading with the Crow tribe.

Competition with the Hudson’s Bay Company and the Rocky Mountain Fur Company increased, worsening their financial situation. By this time, the company also included William H. Vanderburgh, Lucien Fontenelle, and Andrew Drips. In one year alone, they sent out nearly 300 traders who accumulated $42,000 in furs.

But it wouldn’t be enough. On May 31, 1823, a large Blackfeet war party ambushed Pilcher’s men, killing seven and wounding four others. They stole their traps, pack horses, and pelts. Losing about $15,000, Joshua Pilcher pulled his men back from the Northwest, but the ambush dealt a death blow to the company. They never returned to the Northwest, and by the spring of 1824, the Missouri Fur Company was bankrupt.

 

By Kathy Alexander/Legends of America, updated October 2026.

Also See: 

Explorers, Trappers & Traders

Fur Trading in the American West

The Great Fur Trading Companies

Manuel Lisa – Expert on the Missouri River

See Sources.