Many of the conflicts that occurred in Ohio were continuations of conflicts that occurred early in the first encounters between Europeans and Native Americans. These conflicts resulted from either misunderstandings or one side trying to take advantage of the other during trading.

Early traders between Indians and Europeans on the Ohio frontier were primarily between the French because they were the first to explore the area and set up numerous trading posts throughout the Ohio country. The French had long been exploring North America, and they claimed it due to this exploration dating back to the early 1500s.

For many years, the French represented the only traders with the Native Americans in Ohio. However, not everyone was happy with the situation, and an early rebellion against the French traders began in Ohio in 1747. At that time, Miami Chief Memeskia led an organized rebellion against the French, which led to the burning of a French trading post just south of present-day Toledo, Ohio. Years later, the British built Fort Miami on the site.

Another conflict between Europeans and Native Americans occurred in 1752, just before the French and Indian War. A French military expedition from Canada claimed the entire Ohio Valley, leading the French to claim ownership at a place near present-day Piqua, Ohio.